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PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with <t>H‐151.</t> (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
H 151, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sting antagonist h 151  (MedChemExpress)
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PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with <t>H‐151.</t> (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Sting Antagonist H 151, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with <t>H‐151.</t> (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Sting Inhibition, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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sting inhibitor h 151  (MedChemExpress)
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MedChemExpress sting inhibitor h 151
PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with <t>H‐151.</t> (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Sting Inhibitor H 151, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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hy  (MedChemExpress)
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MedChemExpress hy
PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with <t>H‐151.</t> (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
Hy, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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h151  (MedChemExpress)
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MedChemExpress h151
PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with <t>H‐151.</t> (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.
H151, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/h+151/H-151/pm41806931-52-9-19
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PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with H‐151. (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Journal: Advanced Science

Article Title: CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

doi: 10.1002/advs.77280

Figure Lengend Snippet: PFOA/HFPO‐TA exposure activates the cGAS‐STING pathway and induces cardiac senescence. (A,B) Protein levels of PERK, cGAS, eIF2α and STING. (C) SA‐β‐gal staining images of hearts from different groups. (D–F) Western blotting images and quantitative results of proteins. (G) qRT‐PCR analysis of SASP factors in heart tissues. (H) Representative IF images and fluorescence intensity of p21 and p16 proteins. (I) Validation of cGAS knockdown efficiency in HL‐1 cells. (J) Quantitative results of cGAS, p‐PERK, and p‐eIF2α. (K,L) Protein levels of p21 and p16 in cGAS knockdown experiments. (M) Western blot analysis of HL‐1 cells treated with H‐151. (N‐O) Protein levels of p21 and p16 in HL‐1 cells treated with H‐151. (P,Q) SA‐β‐gal staining of HL‑1 cells from cGAS knockdown and STING inhibitor experiments. Data are presented as the mean ± SD, n = 3. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001.

Article Snippet: For cellular stimulation, HL‐1 cells were treated with different reagents, including 20 nM Baf A1 and 1 μM H‐151 (MCE, USA).

Techniques: Staining, Western Blot, Quantitative RT-PCR, Fluorescence, Biomarker Discovery, Knockdown